Ethylenediaminetetraacetic acid (EDTA) is the aminopolycarboxylic acid. It is the disodium salt form of edetate, a polyvalent chelating agent with anti-hypercalcemic and anti-arrhythmic properties. Edetate, a heavy metal chelating agent, forms soluble stable complexes which are readily excreted by the kidneys, thereby can be used to lower serum calcium concentrations. Disodium edetate is used as a chelating agent in a wide range of pharmaceutical preparations, including mouthwashes, ophthalmic preparations, and topical preparation, typically at concentrations between 0.005 and 0.1 % w/v. Disodium edentate is also used as a water softener as it will chelate calcium and magnesium ions present in hard water.
IUPAC NAME OF EDTA:
Disodium Edetate, EDTA disodium salt, 139-33-3, Titriplex III, Edta disodium, Disodium EDTA, Disodium salt of EDTA, Chelest B, Komplexon III, Clewat N, Disodium edathamil, Disodium edta, anhydrous, Zonon D, Dotite 2NA, Selekton B2, Tetracemate disodium, Cheladrate, Mavacid ED4, Versonol 120, Ethylenediaminetetraacetic acid disodium salt, Chelest 200, Disodium versene, Endrate disodium, Sodium versenate, Metaquest B, Kiresuto B, Veresene disodium salt, Chelaplex III, Complexon III, Diso-Tate, Chelaton III, Versene NA, Ethylenediaminetetraacetic acid, disodium salt,Triplex III, Chelaton 3
It is white crystalline powder, having melting point 240°C and boiling point 252°C.
SOLUBILITY AND pH:
It is soluble in water having pH 5.3
All of the industrially used methods of manufacture of Disodium Edetate and its salts involve the addition of formaldehyde and hydrogen cyanide or an alkali metal cyanide to an aqueous solution of Disodium Edetate. The salts, or edetates, are then formed by hydrolysis. Disodium Edetate can also be formed by heating tetrahydroxyethylethylenediamine with sodium or potassium hydroxide using a cadmium oxide catalyst. Disodium EDTA was prepared by dissolving Disodium Edetate into a hot solution that contained two equivalents of sodium hydroxide. The solution was then allowed to crystallize.
HOW TO PREPARE 0.1M DISODIUM EDETATE (EDTA) :
Dissolve 37.5g of Sodium Edetate in 500ml water. Add 100ml of 1M Sodium Hydroxide and mix. Now dilute the solution to 1000ml with water.
HOW TO STANDARDIZE 0.1M DISODIUM EDETATE(EDTA):
Dissolve 0.120g of Zinc in 4ml of Hydrochloric acid. Add dilute sodium hydroxide solution until the solution is weakly acid. Now carry out the assay of zinc by complexometry. 1ml of 0.1M Disodium Edetate is equal to 6.538mg if Zinc.
HOW TO PREPARE 0.05M DISODIUM EDETATE(EDTA):
Dissolve 18.6g of Disodium Edetate in sufficient water to produce 1000ml.
HOW TO PREPARE 0.02M DISODIUM EDETATE(EDTA):
Dissolve 7.444g of Disodium Edetate in sufficient water to produce 1000ml.
HOW TO PREPARE 0.01M DISODIUM EDETATE:
Dissolve 3.722g of Disodium Edetate in sufficient water to produce 1000ml.