Chemistry in pharmaceutical
MOHR’S METHOD OF DETERMINATION OF CHLORIDES BY TITRATION WITH SILVER NITRATE is one of the oldest titration methods still in use – it was researched and published by Karl Friedrich Mohr in 1856.The idea behind this titration is very simple – chlorides are titrated with the silver nitrate solution in the presence of chromate anions. … Read more
Accuracy In analytical chemistry, the term ‘accuracy’ is used in relation to a chemical measurement. The International Vocabulary of Basic and General Terms in Metrology (VIM) defines accuracy of measurement as… “closeness of the agreement between the result of a measurement and a true value.” The VIM reminds us that accuracy is a “qualitative concept” … Read more
Minimizing Systematic Error Systematic error can be difficult to identify and correct. Given a particular experimental procedure and setup, it doesn’t matter how many times you repeat and average your measurements; the error remains unchanged. No statistical analysis of the data set will eliminate a systematic error, or even alert you to its presence. Systematic … Read more
Pharmaceutical Errors Pharmaceutical mistakes cause more than one million serious injuries or deaths in the United States each year. Pharmaceutical errors are generally preventable, and they can result in a type of medical malpractice lawsuit. A pharmaceutical error can happen at any point in the prescription process from the time the medication is picked to … Read more
Alcohol Number Determination represents the number of milliliters of ethanol at 15°C obtained from 10mL of tincture or other preparations containing ethanol by the following Methods. A: Method 1 (Distilling method) This is a method to determine the Alcohol Number by reading the number of milliliters of ethanol distillate at 15°C obtained from 10 mL … Read more
Here is the list of factors for some raw material in B.P and U.S.P. By using these factors you can remove unwanted chemical groups from active and effective one. According to your label claim and raw material. I explain, let one has Lincomycin HCl and label claim for drug is only lincomycin then one should … Read more
ABOUT: Gentamicin Sulfate is the sulfate of a mixture of aminoglycoside substances having antibacterial activity produced by the growth of Micromonospora purpurea or Micromonospora echinospora. PHYSICAL APPEARANCE: Gentamicin Sulfate occurs as a white to light yellowish white powder. It is highly hygroscopic. CHEMICAL FORMULA: C21H43N5O7. xH2SO4 CHEMICAL STRUCTURE: MOLECULAR WEIGHT: 477.60 IUPAC NAME: (6R)-2-Amino-2,3,4,6-tetradeoxy-6-methylamino-6-methyl-α-D-erythrohexopyranosyl-(1→4)-[3-deoxy-4-C-methyl-3-methylamino-β-L-arabinopyranosyl-(1→6)]-2-deoxy-Dstreptamine sulfate … Read more
DESCRIPTION: Diclofenac Sodium is white or slightly yellowish, slightly hygroscopic, crystalline powder. CHEMICAL FORMULA: C14H10Cl2NNaO2 CHEMICAL STRUCTURE: MOLECULAR WEIGHT: 318.1 Dalton USE AS: Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory. IUPAC NAME: Sodium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate. CONTENTS: It contains not less than 99.0% and not more than 101.0% of C14H10Cl2NNaO2. SOLUBILITY: Sparingly soluble in water. Freely soluble in Methanol. Soluble … Read more
White Crystalline powder, Slightly hygroscopic. On dried basis, It contains 98.0% to 102.0% of Pregabalin. Chemical Formula: C8H17NO2 Chemical Structure SOLUBILITY Soluble in Water Slightly Soluble in Methanol Very slightly soluble in ethanol Practically insoluble in acetone, ethyl acetate, heptane and in methylene chloride IDENTIFICATION BY FTIR SPECTROPHOTOMETER Measure the FTIR spectra of sample and … Read more
Physical Appearance : Tranexamic Acid occurs as white, crystals or crystalline powder. It belongs to antifibrinolytic family. Tranexamic Acid, when dried, contains not less than 98.0% and not more than 101.0% of tranexamic acid (C8H15NO2) Structural formula: Chemical Formula (C8H15NO2). Solubility: It is freely soluble in water, and practically insoluble in ethanol (99.5). Identification … Read more